4/13/2023 0 Comments Hengstler grado 921 manual muscleThe suitability of the two in vitro test systems for assessing genotoxic and teratogenic effects of marine sediment extracts could be demonstrated. The toxic potential was more pronounced in fractions having polarity higher than those possessed by PAHs and PCBs. ![]() Polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) are not likely to be the causes of the observed effects, as demonstrated by a two-step fractionation procedure of selected extracts. Highest teratogenic and genotoxic effects normalised to total organic carbon (TOC) content were detected in sediment samples of different origins. EC 50 values were calculated from dose-response curves for both test systems. The comet assay based on the fish cell line Epithelioma papulosum cyprini (EPC) was applied to determine the genotoxic potential zebrafish embryos (Danio rerio) were used to quantify the teratogenic potential of the samples. ![]() Organic extracts of marine sediments from the North Sea and the Baltic Sea were investigated with two toxicity assays. Kammann, Ulrike Biselli, Scarlett Huehnerfuss, Heinrich Reineke, Ninja Theobald, Norbert Vobach, Michael Wosniok, Werner International Nuclear Information System (INIS) ![]() ![]() Genotoxic and teratogenic potential of marine sediment extracts investigated with comet assay and zebrafish test
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